ZIA CP010144-07160 (ZIA) | |||
---|---|---|---|
Title | ITCLC Familial Testicular Cancer Projects | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Greene | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $163,073 | Project Dates | 07/01/2002 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Testes (100.0%) | ||
Research Type | |||
Normal Functioning Endogenous Factors in the Origin and Cause of Cancer |
|||
Abstract | |||
The Clinical Genetics Branch has become a member of the International Testicular Cancer Linkage Consortium ("ITCLC"), a scientific collaboration dedicated to mapping and cloning the genes related to testicular cancer susceptibility in humans. There are three components to our collaboration with the ITCLC: 1. We are contributing DNA from newly-ascertained US testicular cancer families to this international gene identification effort. 2. We are capitalizing on the large set of European families which has already been assembled by the ITCLC by taking the scientific lead in designing and conducting twoadditional studies: (a) a centralized review of the pathology of a large series of familial testicular cancers and a comparison group of non-familial testicular cancers. (b) a formal, quantitative analysis of the occurrence of cancers other than testicular cancer in these families. 3. We are performing a descriptive analysis of the ITCLC testicular cancer family set (n=500) 4. We are pooling DNA samples collected from members of multiple-case families and from sporadic, bilateral testicular cancer patients to assess the contribution of selected candidate genes as either high-penetrance or low- penetrance genetic modifiers of testicular cancer risk. |